BoneFill: Mimicking bone chemistry within injectable bone-filler: highly improved bioactivity for faster small defect regeneration
| Project code: | J2-70087 Basic, Bilateral |
| Call: | Weave Poland-Slovenia |
| Financed by: |
Slovenian Research and Innovation Agency (ARIS)
|
| Duration: |
2026 - 2029 |
| Principal Investigator: | Dr Aneta Szymańska (Department of Biomedical Chemistry, Faculty of Chemistry, University of Gdansk, Poland), Asst. Prof Marija Vukomanović (K9) |
Highly bioactive fillers, designed to mimic the natural bone chemistry and characterized by osteoinductive, osteoconductive and osseointegrative nature, are aimed to be developed within the proposed project. The important part of the design is the chemistry of the bioactive components - including bone-like multi-doped hydroxyapatite (mHAp), biodegradable and biocompatible polymer and bioactive peptides within an injectable matrix. The healing strategy predicts injecting the matrix to fit the size and shape of bone defect, solidifying the matrix after UV-crosslinking and local, matrix-controlled release of active components. The collaboration will include bioactive mHAp design at Jozef Stefan Institute (JSI), surface functionalization with bifunctional bioactive and antimicrobial peptides at University of Gdańsk (UG) and crosslinked matrix design at Wrocław University of Science and Technology (Wrocław Tech.). The final proof of the concept will include matrix biodegradation and release of bioactive components (Wrocław Tech., UG, JSI), as well as confirming the prevention of bacterial colonization (JSI), and stimulative and osteoconductive nature of injectable matrix with loaded bioactive components (Faculty of Pharmacy, University of Ljubljana (FFA).
Highly bioactive fillers, designed to mimic the natural bone chemistry and characterized by osteoinductive, osteoconductive and osseointegrative nature, are aimed to be developed within the proposed project. The important part of the design is the chemistry of the bioactive components - including bone-like multi-doped hydroxyapatite (mHAp), biodegradable and biocompatible polymer and bioactive peptides within an injectable matrix. The healing strategy predicts injecting the matrix to fit the size and shape of bone defect, solidifying the matrix after UV-crosslinking and local, matrix-controlled release of active components. The collaboration will include bioactive mHAp design at Jozef Stefan Institute (JSI), surface functionalization with bifunctional bioactive and antimicrobial peptides at University of Gdańsk (UG) and crosslinked matrix design at Wrocław University of Science and Technology (Wrocław Tech.). The final proof of the concept will include matrix biodegradation and release of bioactive components (Wrocław Tech., UG, JSI), as well as confirming the prevention of bacterial colonization (JSI), and stimulative and osteoconductive nature of injectable matrix with loaded bioactive components (Faculty of Pharmacy, University of Ljubljana (FFA).